What is Enclomiphene? Enclomiphene Citrate is a non-steroidal selective estrogen receptor modulator (SERM) that is isolated from Clomiphene and Zuclomiphene. Enclomiphene works by antagonizing estrogen receptor feedback, thus signaling more gonadotropin secretion and gonadal production of testosterone in the body. Compared to its stereoisomer counterpart, Zuclomiphene is the more anti-estrogenic compound of the two. Due to this antiestrogenic property enclomiphene has been isolated to treat male hypogonadism and raise total and free testosterone levels. Enclomiphene also stimulates both Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). Studies have proven enclomiphene to be successful in increasing serum testosterone levels in men with low and mid-ranged testosterone levels as well as keeping dihydrotestosterone (DHT) proportionate. This proportionality in DHT to total testosterone levels is crucial in hormonal health as well as the health of your hair.
How Does This Benefit You? As a bodybuilder or someone who is interested in their overall health, testosterone levels play an important part of your mental health, overall health and your physical goals. Making sure that these levels are adequate can bring a multitude of benefits to your everyday life. By taking and dosing enclomiphene citrate properly (6.5-25mg), you can see an increase in testosterone levels of the body, which in turn could provide that extra boost in the gym, to your physique or raise your testosterone levels from below average to average or even above average. Regardless of your goals or usage of the drug, it has been shown in multiple studies to benefit total testosterone at any level and dosage.
The graph from this particular study shows Enclomiphene administered throughout a 6 week period in a blind study compared to 10mg of Testosterone gel and various dosages of enclomiphene. Nearly 60% of men in the study that were given the highest dosages of enclomiphene exhibited testosterone less than 300ng/dL. After 6 weeks of 25mg of enclomiphene administration daily, the number of men who had testosterone in the 300-1000 ng/dL range was 100%. When compared to the chart we see that 25mg of Enclomiphene led to 67% of subjects having a final testosterone level of >500ng/dL compared to 46% in the transdermal testosterone gel group. The results of this study concluded that the mean testosterone of those treated with 25mg of enclomiphene was 604ng/dL compared to the transdermal testosterone group mean value of 500 ng/dL Not only does this study conclude that the administration of enclomiphene citrate increased testosterone in hypogonadal men, but it was able to increase testosterone levels of men with adequate levels of testosterone already. These findings from this particular study show that Enclomiphene supplementation in men has been shown to increase total testosterone as much as some TRT methods such as testosterone gel. These findings could be utilized in many ways. People on the fence about the commitment of TRT (Testosterone Replacement Therapy) or exogenous testosterone may be more inclined to use enclomiphene as a testosterone-boosting alternative. Enclomiphene can boost testosterone levels or help people looking for a “gray area” substance to utilize for gym performance.
T*Graphs show LH and FSH levels with Enclomiphene and Testosterone gel groups throughout a 6-week period. Testosterone gel groups are represented with Triangles. 25mg Enclomiphene in Red Squares. 12.5 in Green Squares and 6.25 in Hollow Squares.*
A Deeper Dive. Further strengthening the case for enclomiphene. In men with low and normal baseline testosterone levels we see yet another study where the mid-maximum dosage of enclomiphene was more effective than transdermal testosterone gel. A 14-day study was done with 4 groups, placebo, 25mg of Enclomiphene; 50mg Enclomiphene administration daily, and 10g of testosterone gel daily. The enclomiphene groups maintained and finished the study with testosterone levels from 400-700 ng/dL and had proportional DHT levels to their respective total testosterone level. The group who had been administered testosterone gel had experienced a similar increase in total testosterone as the enclomiphene group, yet they suffered from disproportionate DHT levels in the body. Both the men in this study and the aforementioned study above maintained fertility and increased sperm count in the men who were administered Enclomiphene compared to the testosterone gel and control group. In conclusion to both studies, it seems that a dosage of 12.5-25mg of enclomiphene yields superior results. In the first study done, the data shows that peak testosterone increases and increases in luteinizing hormone (LH) were seen in the 25mg group. Additionally, alongside this increased dosage in Enclomiphene, the group also saw a suppression of IGF-1 levels in the body. Levels remained normal but did dip slightly. Overall, the conclusion from the studies is that higher doses of Enclomiphene were able to restore and boost testosterone, LH, and FSH as well as keep DHT proportionate. These increased testosterone levels were seen on a graph and mimicked the hormonal curve of men in their early to mid-20s, showing that testosterone was indeed produced and increased by the body. Findings showed that these increased levels remained even weeks after administration.
*This information is not advice or any procedure to administer Enclomiphene, please take utmost safety precautions and health precautions when taking any type of drug/medicine. This information is for educational use only*
Anecdotal Experience and Dosage. When supplementing with Enclomiphene I personally have only gone up to 12.5 mg. At this dosage, I have experienced increased libido, semen volume, increased strength, increased sexual performance, and performance in the gym as well as testicular growth. At this dosage, I felt more alert, on edge, and increased mental clarity. Since enclomiphene administration I've had increased performance in the gym. This increased performance could be due to external factors such as being in a caloric surplus. One thing that I have experienced was increased recovery. I felt that I could push harder, specifically on chest days. Bench Press, barbell press, bicep strength, and overall pressing strength have skyrocketed since the administration of 12.5 mg of enclomiphene daily. I was able to push past bench plateaus, reach a 275lb benchpress, and bring up my chest strength which was lacking in comparison to my shoulders. Overall the results I have experienced with Enclomiphene have occurred within a somewhat short period of time (8-10 week experiment). Throughout this time all of my lifts have increased, my strength has increased, my overall health and well-being have improved and I’ve experienced sexual benefits as well. These anecdotal findings compare and line up with common results found in the three studies linked in the article. To avoid side effects Enclomiphene should be used in a cutting or mid-bulk phase. When cutting, Enclomiphene administration would allow the body to produce more testosterone instead of testosterone being lowered due to an increased caloric deficit. On the other hand, if enclomiphene was used during the beginning or mid phases of a bulk it would allow for a boost in testosterone production, potentially allowing more strength gains to be made.
Safety & Conclusion. Enclomiphene Citrate is an effective way to raise total testosterone levels, FSH, and LH all while keeping DHT levels proportionate in the body. Enclomiphene can be utilized by people exhibiting low testosterone levels, people who want to boost their testosterone, or gym-goers who want that extra boost or want to increase their testosterone. Regardless of your goals for the substance, it has been shown to increase total testosterone in hypogonadal men and men with mid range testosterone levels. Studies have shown that enclomiphene administration helps men reach a hormonal curve similar to men in their early 20s. The increases in testosterone have been maintained for weeks after administration. Enclomiphene can be run as long as the user would like, with effects dwindling after supplementation has ended. Side effects of enclomiphene include eye floaters and an increase in estrogen due to the aromatization of testosterone. Enclomiphene also increases and preserves sperm volume and fertility compared to TRT treatments which have the opposite effect. Dosages ranging from 12.5-25mg of enclomiphene have been shown to be as effective as transdermal testosterone gel. In comparison, enclomiphene seems superior due to the fact that it does not suppress the body's natural testosterone production but it in fact utilizes the body to produce more testosterone “naturally”. Overall, Enclomiphene seems to be an effective gray area substance to take as an alternative to the commitment of TRT or any steroids.
*All information is for educational purposes only. Please research and use these substances responsibly over the age of 21*
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Citations
1- https://resolver.ebscohost.com/openurl?
2- https://www.liebertpub.com/doi/full/10.1089/jomh.2014.0006
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